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譜析（上海）生物科技有限公司提供——Antiasthmatics in Plasma 質譜診斷方案
 
一、說明
Theophylline, theobromine and caffeine are termed as methylxanthines and are used in the management of asthma bronchiale. Methylxanthines produce a relaxation of the bronchial smooth muscle and thus are helping to open up constricted airways (bronchodilators). The drug absorption and metabolism may be affected by many factors, including co-medication with other drugs (e.g. several AEDs). A monitoring of the plasma level is therefore essential to ensure that therapeutic, but not toxic drug doses are applied. The RECIPE ClinRep@ Complete Kit features simple and quick sample preparation, a cost efficient analysis and ensures reliableres.
 
二、產品優勢
（1）Simultaneous determination of 3 methylxanthines
（2）Simple and quick sample preparation
 
三、測試數據
Linearity:                  1.3 - 50 mg/1
Recovery:                   approx. 70 %
LOD:                        Theophylline:        0.8 mg/l
Theobromine:         0.6 mg/l
Caffeine:            0.6 mg/l
LLOQ:                       Theophylline:        1.7 mg/l
                            Theobromine:         1.3 mg/l
                            Caffeine:            1.4 mg/l
Intraassay precision:      2.5 %
Interassay precision:       1.7 %
 
四、高效液相色譜參數
Pump:                       isocratic pump, flow rate: 1.5 ml/min
Injection volume:           20 μI
Injection interval:         8 min
UV/VIS-Detector:            273 nm
HPLC-Thermostat:            37°C 
 
 
五、樣品制備
 
 
 
六、訂購信息
 

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